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KMID : 0363320030240010033
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Journal of Korean Oriental Internal Medicine
2003 Volume.24 No. 1 p.33 ~ p.43
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The effects of the abstracts from Moutan Cortex on an anti-allergic action on B cells and mast cells of the BALB/C mouse
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Jang Sung-Ik
Jeen Sok-Chang
Lee Han-Bae
Kim Sung-Kyun
Lee Seung-Hee
Seo Young-Bae
Lee Yong-Gu
Lee Young-Chul
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Abstract
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Objective : This study was carried out for the purpose of proving the effect of anti-allergic efficacy on B cells and the mast cells of the BALB/C mouse by the abstraction from a Moutan cortex.
Methods & Results : In order to know what the effect of an abstraction from Moutan cortex and about the expression of CD23 and IgE, IC-2 cell (mouse mast precursor cells that was dependent on IL-3), it was necessary to be activated. We then analyzed it from the flow of cytometry on the increase and the divorce of the B cells activated by anti-CD40. In order to know what the effect of it was on the organization of cytokine gene expression from the increase and divorce of the B cells and allergic acting by Moutan cortex, we found it necessary to examine the IC-2 cells and B cells. At the same time, as we examined the histamine release of IC-2 cells by ELISA method, we also examined the effect of Moutan cortex on the increase and divorce of the B cells by 3H-thymidine uptake method. We then analyzed the release of IL-4, IgE and histamine.
Conclusions : As a results, Moutan Cortex promoted blood supply by extending the blood vessel of nasal mucous, which was contracted by the hypertrophied nasal mucous.
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KEYWORD
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Moutan cortex, B cells, the mast cells, Anti-allergic action
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